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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
4.55
Human Site:
Y42
Identified Species:
8.33
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
Y42
G
L
E
L
H
P
D
Y
K
T
W
G
P
E
Q
Chimpanzee
Pan troglodytes
XP_514624
382
43769
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
Y144
G
L
E
L
H
P
D
Y
K
T
W
G
P
E
Q
Dog
Lupus familis
XP_542986
665
76981
H80
G
R
E
L
R
P
D
H
Q
S
W
G
P
E
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
D42
D
D
D
F
Q
N
T
D
L
R
T
W
E
P
E
Rat
Rattus norvegicus
XP_230789
677
77635
R102
D
P
E
S
S
D
L
R
T
W
G
P
E
D
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
H45
D
T
E
R
L
C
Q
H
L
S
R
N
G
V
G
Frog
Xenopus laevis
Q6INN8
632
72730
R42
G
Q
T
A
A
N
Y
R
E
W
D
V
E
E
V
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
A44
G
E
G
L
Q
E
W
A
Q
I
F
K
D
N
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
P42
M
N
W
Q
S
L
E
P
K
H
I
I
N
D
N
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
G45
G
K
G
F
S
E
E
G
G
I
M
T
R
G
N
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
0
100
66.6
N.A.
0
6.6
N.A.
N.A.
6.6
13.3
13.3
N.A.
N.A.
N.A.
6.6
6.6
P-Site Similarity:
100
0
100
86.6
N.A.
13.3
13.3
N.A.
N.A.
20
20
26.6
N.A.
N.A.
N.A.
20
13.3
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
0
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
24
8
8
0
0
8
24
8
0
0
8
0
8
16
0
% D
% Glu:
0
8
39
0
0
16
16
0
8
0
0
0
24
31
8
% E
% Phe:
0
0
0
16
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
47
0
16
0
0
0
0
8
8
0
8
24
8
8
16
% G
% His:
0
0
0
0
16
0
0
16
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
16
8
8
0
0
0
% I
% Lys:
0
8
0
0
0
0
0
0
24
0
0
8
0
0
0
% K
% Leu:
0
16
0
31
8
8
8
0
16
0
0
0
0
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
8
0
0
0
16
0
0
0
0
0
8
8
8
16
% N
% Pro:
0
8
0
0
0
24
0
8
0
0
0
8
24
8
0
% P
% Gln:
0
8
0
8
16
0
8
0
16
0
0
0
0
0
24
% Q
% Arg:
0
8
0
8
8
0
0
16
0
8
8
0
8
0
0
% R
% Ser:
0
0
0
8
24
0
0
0
0
16
0
0
0
0
0
% S
% Thr:
0
8
8
0
0
0
8
0
8
16
8
8
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
16
% V
% Trp:
0
0
8
0
0
0
8
0
0
16
24
8
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
16
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _